Radical cancer surgery has become today a more and more preferred medical treatment, thus confirming the awareness that chemotherapy is unable to eradicate the tumor. Under many circumstances MDB treatment may be associated to surgical removal of the tumor, keeping in mind that the tumor is only the maximum concentration in one point of a generalized and systemic disease. Therefore the eradication of a neoplastic focus may be useful especially if preceded by MDB treatment for a couple of weeks, as this would dramatically reduce the proliferation and invasion of tumor cell populations, which on the contrary surgery often causes to be easily disseminated in the body. Such potential dissemination and consequent metastases are definitely inhibited by MDB antitumor activity. Hence, surgery should be preceded, accompanied and followed by MDB treatment.